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KMID : 0376219670040010071
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Chonnam Medical Journal
1967 Volume.4 No. 1 p.71 ~ p.79
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Arrhythmia Produced by Combined Actions of 5-Hydroxytryptamine and Sympathomimetic Amines and Effect of Quinidine on it
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Abstract
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In urethane-anesthetized rabbits, intravenous 5-HT preceded by intravenous sympathomimetic amines produced ectopic beats. No intimate relationship was found between incidence of arrhythmia and the reflexive cardiac slowing produced by 5-HT. This suggested a direct action of 5-HT on heart to produce the ectopic beats.
Intravenous or intraventricular quinidine did not prevent the arrhythmia produced by combined actions of 5-HT and sympathomimetic amines, but exacerbate it in some instances. Quinidine produced a transitory depressor response in normal anesthetized rabbits, whereas it produced pressor response preceded by depression in reserpine-treated rabbits. This suggested some pharmacologic actions of quinidine might be related to sympathetic activity.
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